《英文msh詞典》Protein Receptor,Cell-Adhesion
[入口詞] Protein Receptor,Cell-Adhesion
[主題詞] Integrins
[英文釋義] A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT,and other cells,while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS,CYTOADHESIN),the leukocyte adhesion receptors (RECEPTORS,LEUKOCYTE ADHESION),and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes,including embryological development,HEMOSTASIS,THROMBOSIS,WOUND HEALING,immune and nonimmune defense mechanisms,and oncogenic transformation.